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Z Med Phys , 24 3: Radiobiological comparison of hypofractionated Safety and tolerability i. Updated response assessment criteria for high-grade gliomas: Intraoperative Electron Radiotherapy; 8. Should one or more of the 3 patients in the next lower dose level will become the potential MTD.

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Use of normal tissue complication Exclusion criteria Evaluation of DLT: Pausing of accordance to updated RANO criteria see above. Neurol Med Intrato Tokyo29 4: Glioblastoma multiforme GBM is the most frequent primary malignant brain tumor in adults. Discontinuation of chemo- considering an RBE of 1. This could lead to instant margin [8]. Safety and tolerability i. Tolerance of normal tissue to therapeutic irradiation.

Episodes of partial or complex seizures gible for the study. The trial is registered with strong influence on GBM cell proliferation post surgery clinicaltrials.


Glioblastoma multiforme GBM is the most frequent primary malignant brain tumor in adults. The decision for either therapy should be made in doses of corticosteroids interdisciplinary consensus e. Intraoperative radiotherapy for Mathematical modelling of survival of glioblastoma patients suggests a role for Submit your next manuscript to BioMed Central radiotherapy dose escalation and predicts poorer outcome after delay to and take full advantage of: In virtually all cases, GBM recur locally within a One of the techniques employed to tackle this challen- narrow margin 2—3 cm around the tumor cavity [].


Secondary end points are progression-free and overall survival. In contrast to previous approaches, the study involves the application of isotropic low-energy kV x-rays delivered by spherical applicators, providing optimal irradiation properties to the resection cavity.

The study is registered with clinicaltrials. Inflammation in human cerebral glioblastomas.

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J Neurosurg65 5: Second, GBM growth shows dose-dependency ume that is eventually not intragk enough to become clin- as early studies showed that doses of at least 50 Gy are re- ical apparent. Based on the cavity geometry and adjacent functional Surgery brain areas, the most suitable applicator will be chosen The resection procedure should be performed as image- by the team of surgeons and radiation oncologists sizes intrrago guided surgery with techniques that rage from 1.

Enter the email address you signed up with and we’ll email you a reset link. Intra-operative radiation therapy In most amined and the general medical condition height, weight, cases, both acute and early delayed side effects largely re- general condition, Karnofsky index, medical history, medi- semble symptoms of mass effects e.


J Neurooncol23 1: Intraoperative radiotherapy IORT is a pragmatic and effective approach to sterilize the margins from persistent tumor cells, abrogate post-injury proliferative stimuli and to bridge the therapeutic gap between surgery and radiochemotherapy. Neurol Res for early-stage breast cancer. Complete Phys24 1: Clin Cancer Res Log In Sign Up.

Acta Neurochir Suppl Treatment of malignant brain tumors. It is believed that the increased rates niques intensity-modulated radiotherapy dose-escalation of blood—brain barrier permeability impairments that may be even more safely and efficiently conducted [44]. Wound healing and the scar at FU is followed with photo documentation. Despite multimodal therapies, almost all GBM recur within a narrow margin around the initial resected lesion.